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While dramatic advances in human well-being have been achieved worldwide through technological and institutional innovations in agri-food systems, adverse impacts on climate, the natural environment, public health, and social justice increasingly impede further, sustained progress. How humanity can innovate to bring about local and global agri-food systems that more equitably, healthfully and sustainably expand on past progress is the fundamental question posed in Socio-Technical Innovation Bundles for Agri-Food System Transformation (Palgrave Macmillan, 2022), a synthesis of the current state of the world’s agri-food systems, and an examination of key external drivers of change anticipated over the next 25–50 years. In a Chats in the Stacks book talk hosted by Mann Library in October 2022, co-authors Chris Barrett, Rebecca Nelson, Mario Herrero, and Daniel Mason-D'Croz discuss the report, commissioned by the Cornell Atkinson Center for Sustainability and the journal Nature Sustainability.